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DESCRIPTION

Basic Info

Color	White
Grade	Pharmaceutical Grade
Transport Package	Alumininum Foli Bags
Specification	10g, 50g, 200g, 1kg, 5kg
Trademark	hhdpharm
Origin	China

Product Description

Wuhan Hhd Supply Active Pharmaceutical Ingredient Entecavir Hydrate / Entecavir Monohydrate

Product Name:	Entecavir Monohydrate
CAS:	209216-23-9
MF:	C12H17N5O4
MW:	295. 29448
EINECS:	606-668-5
Product Categories:	API;Baraclude; Liver Disease Series
Molecular Structure:

Product Information

Entecavir is a deoxyguanosine nucleoside analogue with antiviral activity against the hepatitis B virus (HBV). The compound has a mechanism of action by inhibiting priming and chain extension through inhibition of HBV DNA polymerase. Entecavir is also documented as the most potent HBV DNA polymerase inhibitor and superior to Lamivudine (sc-221830) due to its effectiveness against Lamivudine resistant HBV strains and being 30 fold more active.

Function

This product is a nucleoside analogue of guanine, which has inhibitory effect on hepatitis B virus (HBV) polymerase. It can be converted into active three phosphate by phosphorylation, and the half-life of three phosphate in cells is 15 hours. The natural substrate and HBV polymerase three phosphate deoxyguanosine competition, entecavir three phosphate can inhibit the viral polymerase (reverse transcriptase) of all three activities:(1) HBV polymerase promoter;(2) before the formation of genomic mRNA reverse transcription negative strand synthesis;(3) HBV DNA is the chain.The inhibitory constant (Ki) of entecavir three phosphate against HBV DNA polymerase was 0.0012 mu M. Entecavir three phosphate inhibited the alpha, beta, Delta DNA polymerase, and mitochondrial gamma DNA polymerase of cells less, and the Ki value was 18, as far as 160 M.

Appliction

1.Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection.

2.Entecavir is a nucleoside analog (more specifically, a guanosineanalogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. The drug's manufacturer claims that entecavir is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir).

3.It also helps prevent the hepatitis B virus from multiplying and infecting new liver cells. Entecavir is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection.